In the past eight years, the THSTI has grown from an idea to an institution that is ready to take its place with leading science institutions in the country, but differentiates itself by being aimed beyond discovery research, to the fostering of application through its own efforts and through partnerships. THSTI has five areas identified as 'star' projects where we will develop world-class research and translational programs. These are i) vaccines, ii) maternal and child health, iii) point-of-care diagnostics, iv) metabolic diseases and nutrition, and v) training in clinical and product development. All of these will be pursued in parallel with the creation of an inter-institutional ecosystem in the NCR Biotech Science Cluster focused on the development of an academia-biotech-industry collaboration modeled on the science research parks that are nested within major innovation hubs.