In 1889 it started as an Ayurvedic Patasala during the reign of Sree Moolam Thirunal, at East Fort, Thiruvananthapuram. This later became the Government Ayurveda College. Earlier only 15 students were given training. In 1910 the college began to impart a five-year regular course and those who completed the first four years were awarded L.M.C (Lower Medical Certificate) and those who completed all the five years were given Higher Medical Certificate. From 1917 onwards the degree course was titled "Vaidyakalanidhi". Later the college opened an outpatient counter and pharmacy both of which provided service to the public. The college in 1929 introduced a research degree named 'Ayurvedacharya'. In 1962 the integrated course was terminated and pure degree and diploma courses in Ayurveda were implemented. These were also stopped in 1969 and subsequently in 1971-72 post graduation courses were started. At present the college is affiliated to Kerala University of Health Sciences (KUHS).The College conducts various paramedical courses as well.
1 Auditorium
2 Audio Visual Aid
3 Animal house
4 Classrooms
5 Canteen
6 Casualty management centre
7 Conference Hall
8 Consumer store
9 Co-operative society
10 Dissection hall
11 Demonstration hall
12 Drug standardization unit
13 Herbal garden
14 Hospital
15 Hostel Union Council
16 House Surgeons Assosiation(HSA)
17 Investigation Centers - ECG,Labortary,USG,X-ray
18 Medical Stores
19 Museum
20 National Service Scheme
21 Offices
22 Parent Teachers Association
23 Pharmacy
24 Physical Education Center
25 Physiotherapy Unit
26 Play Ground
27 Post Graduate Students Association-PGSA
28 Publication Division
29 Library
30 Seminar Hall
31 Snake Park
32 Yoga & Meditation Center
Hostel Facility
Hostel Facilities available